The Effect of Nano-chitosan and Nano-curcumin on Radiated Parotid Glands of Albino Rats: Comparative Study

Abstract Decreasing the salivary flow rate manifested by xerostomia occurs early during irradiation treatment. The duration of depressed function varies among patients. Various histopathological changes occur in glands. current study was performed to investigate and compare between possible anti-radiotherapeutic effect gamma rays-synthesized curcumin nanoparticles (Cur NPs), chitosan (Cs NPs). They were utilized overcome associated with radiation therapy albino rats’ parotid Sixty adult male Albino rats utilized, fifteen as control group, radiated group thirty Cur NPs Cs treatment groups. glands dissected examined histologically, immunohistochemically for vascular endothelial growth factor (VEGF) well histo-morphometrically. histological results proved antiradio-therapeutic NPs, least degenerative treated group. A high significant increase VEGF recorded compared other have be an anti-oxidant substrate treating rats. However, it lagging behind all analyses but non-significant differences them been recorded. Graphical